5-HTP of the efficacy and role

September 21st 2022 0 Comments
5-HTP of the efficacy and role

5-HTP is a natural amino acid extracted from the seeds of the African mesquite plant Griffonia simplicifolia.

The seeds are oblong, about 1.5 cm long and 1 cm wide, the seed coat is black, wrinkled, the endosperm is yellow-green, slightly bean aroma, the dried fruit weighs about 80 grams, wild in Africa, Ghana, Cote d’Ivoire and Togo and other West African countries .


5-HTP is a pure natural herb with sedative properties.


It is a precursor to a hormone (serotonin) in the body that helps the body produce this hormone so that it is balanced in the body.


5-HTP is decarboxylated to serotonin (serotonin) by aromatic L-amino acid decarboxylase with the help of vitamin B6.

Efficacy and role

5-Hydroxytryptophan (5-HTP) can be decarboxylated into serotonin (5-HT), also known as serotonin, in the body with the help of vitamin B6.

Serotonin is found in the brain, platelets, stomach, and central nervous system, and it is an important chemical in the brain that controls mood, behavior, appetite, sleep, and impulses.

5-Hydroxytryptophan is a natural alternative to the prescription drug Prozac.

Drugs such as Prozac prevent brain cells from depleting serotonin too quickly, while 5-hydroxytryptophan increases the production of serotonin in brain cells, which contributes to normal nerve and brain function.

Since serotonin is a precursor to melatonin, a natural hormone that regulates sleep and wake cycles, when serotonin levels increase, so do melatonin levels, resulting in sweeter sleep.

Additionally, using 5-hydroxytryptophan can help suppress appetite, allowing the body to consume fewer carbohydrates and feel full faster.

A daily intake of 750 mg of 5-hydroxytryptophan can reduce carbohydrate absorption and achieve weight loss without causing weight gain.

Extraction Method

At present, the extraction technology of 5-hydroxytryptophan includes water extraction and alcohol extraction.

However, in the subsequent purification, the yield is generally not high, the color of the product is poor.

A large amount of unprocessable crystallization mother liquor is produced, which wastes resources and pollutes the environment.

It can also be chemically synthesized.

Raney-Ni and ZnO catalysts, tryptophan, glycolic acid and hydrochloric acid were added to the autoclave for synthesis.