Genistein is a natural isoflavone compound present in legume crops and dentate plants.
A large number of epidemiological investigations, cell culture and in vitro and in vivo and animal experiments have confirmed that genistein is a potent tyrosine protein kinase inhibitor and topoisomerase inhibitor.
Genistein has a wide range of antitumor pharmacological activities, which can inhibit tyrosine protein phosphorylation, inhibit DNA topoisomerase activity, regulate oncogenes, inhibit malignant transformation of cells, inhibit angiogenesis, antioxidant and estrogen-like effects .
1. Regulate oncogenes.
Genistein regulates oncogenes, inhibits specific cell cycles, and inhibits the proliferation, growth and metastasis of malignant cells by inhibiting the activities of tyrosine protein kinases and topoisomerases.
2. Induce apoptosis of malignant cells.
It can block cell agonistic signal transduction, change gene expression, cause cell DNA damage, and induce programmed cell apoptosis, thereby inhibiting tumor growth.
3. Induce cell differentiation.
It has a variety of cell differentiation-inducing effects, which can reverse cancer cells to normal cells or close to normal cells. Stop the development of malignant tumors.
4. Inhibit the malignant transformation of cells.
Genistein significantly inhibits the malignant transformation of cells by altering the expression of oncogenes, thereby preventing the development of precancerous lesions. Prevent the occurrence of cancer.
5. Inhibit tumor angiogenesis.
It specifically inhibits the proliferation of tumor blood vessels and interferes with the formation of new blood vessel network, thereby cutting off the nutrient supply and metastasis pathway of cancer cells, affecting the clone of cancer cells, thereby inhibiting the growth and metastasis of tumors.
6. Antioxidant effect.
Genistein can reduce the level of reactive oxygen species in tumor cells, prevent the development of tumors; and protect the body through antioxidant effects. Reduce the adverse reactions of radiotherapy and chemotherapy.
Genistein antagonizes estrogen antibodies, inhibits excess estrogen, and reduces the occurrence of hormone-related tumors.
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